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January 1, 1994Stem Cells

The structure, biology and potential therapeutic applications of recombinant thrombopoietin

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Why the study?

Does recombinant thrombopoietin stimulate megakaryocytopoiesis and increase platelet production?

Population

Hematopoietic progenitor cells in vitro and mice in vivo

Design

Review

Authors

SLSi LokUniversity of British ColumbiaDFDonald C. FosterUniversity of Minnesota

Discussion

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Implication

Potential therapeutic option for thrombocytopenia; leaves open human efficacy and safety pending randomized trials.

Structured PICO

Does recombinant thrombopoietin stimulate megakaryocytopoiesis and increase platelet production?

P
Population
Hematopoietic progenitor cells in vitro and mice in vivo
I
Intervention
Recombinant thrombopoietin
O
Outcome
Megakaryocytopoiesis and platelet production

Recombinant thrombopoietin is a potent stimulator of megakaryocytopoiesis and platelet production, with potential therapeutic applications for managing thrombocytopenia.

Cite This Study

Lok et al. (1994) studied this question.

synapsesocial.com/papers/6a729cf9f44fa9f079e007abhttps://doi.org/10.1002/stem.5530120606
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily.1992 · 522 citations
  2. 2Therapy of chronic idiopathic thrombocytopenic purpura in adults [see comments]1989 · 213 citations
  3. 3Distinct Classes of Factor-Independent Mutants can be Isolated after Retroviral Mutagenesis of a Human Myeloid Stem Cell Line1993 · 84 citations
  4. 4Recombinant human interleukin-11 stimulates megakaryocytopoiesis and increases peripheral platelets in normal and splenectomized mice1993 · 161 citations
  5. 5The effect of carbohydrate on the structure and stability of erythropoietin.1991 · 196 citations