Key result
The cloning of thrombopoietin has elucidated the molecular mechanisms of megakaryocyte and platelet development, providing new opportunities to manipulate blood cell development for therapeutic benefit.
Design
Review
Authors
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Cloning of thrombopoietin reveals thrombopoiesis pathways; leaves open therapeutic translation in platelet disorders.
The availability of recombinant thrombopoietin provides new therapeutic opportunities to manipulate blood cell development.
Kenneth Kaushansky (1999) conducted a review in Megakaryocyte and platelet development. Thrombopoietin was evaluated. The cloning of thrombopoietin has elucidated the molecular mechanisms of megakaryocyte and platelet development, providing new opportunities to manipulate blood cell development for therapeutic benefit.
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