Why the study?
Does normothermic cardiopulmonary bypass reduce mortality and morbidity compared to hypothermic bypass in adult cardiac surgery?
Population
6,731 adult patients undergoing cardiac surgery with cardiopulmonary bypass, pooled from 44 randomized…
Comparison
Normothermic cardiopulmonary bypass (> 34°C) vs Hypothermic cardiopulmonary bypass (≤34°C)
Design
Meta-analysis
Key result
Maintaining normothermia during cardiopulmonary bypass in adults showed similar mortality to hypothermia (1.4% vs 1.9%; RR 1.38, 95% CI 0.94-2.04) and reduced risk of allogeneic blood transfusion.
Authors
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Normothermia during CPB maintains similar mortality with fewer transfusions; extends Level 1 evidence for its routine use in adult cardiac surgery.
Meta-Analysis (n=6,731)
Yes
Does normothermic cardiopulmonary bypass reduce mortality and morbidity compared to hypothermic bypass in adult cardiac surgery?
Relative Risk: 1.38 (95% CI 0.94–2.04)
Absolute Event Rate: 1.4% vs 1.9%
p-value: p=0.10
Maintaining normothermia during cardiopulmonary bypass in adult cardiac surgery is as safe as hypothermia and is associated with a reduced risk of allogeneic blood transfusions.
Ho et al. (2009) conducted a meta-analysis in adult cardiac surgery (n=6,731). Normothermic cardiopulmonary bypass (> 34°C) vs. Hypothermic cardiopulmonary bypass (≤34°C) was evaluated on Mortality (RR 1.38, 95% CI 0.94-2.04, p=0.10). Maintaining normothermia during cardiopulmonary bypass in adults showed similar mortality to hypothermia (1.4% vs 1.9%; RR 1.38, 95% CI 0.94-2.04) and reduced risk of allogeneic blood transfusion.
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