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Maternal supplementation with the microbial tryptophan metabolites indole or indole-3-acetic acid prevents diet-induced metabolic dysfunction-associated steatotic liver disease (MASLD) and fibrosis in offspring via sustained aryl hydrocarbon receptor (AHR) activation and increased hepatic very long-chain ceramides. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.ESTABLISHES_NEW_DIRECTION.

Reprogramming offspring liver health: maternal indole supplementation as a preventive strategy against MASLD

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