A Tumor-targeting and Mitochondria-anchorable Probe for NIR/MRI Imaging-guided Photodynamic Therapy of Colorectal Cancer

Key Points

• This study aims to develop a novel theranostic probe that targets tumors and anchors to mitochondria for better phototherapy outcomes.
• Designed and synthesized a specific tumor-targeting and mitochondria-anchorable probe.
• Evaluated the effectiveness of the probe in NIR/MRI imaging-guided photodynamic therapy.
• The probe showed significant tumor targeting and accumulation in mitochondrial sites, improving treatment efficacy.
• Enhanced imaging capabilities allowed for precise monitoring of the therapy response.