A Tumor-targeting and Mitochondria-anchorable Probe for NIR/MRI Imaging-guided Photodynamic Therapy of Colorectal Cancer

Chaoxiang Cui; Yurong Fan; Shaokun Hu; Yuqi Zhang; Zhongsheng Zhao; Guohua Fan; Haibin Shi; Wu Cai

doi:10.1039/d6nr01015f

January 1, 2026Nanoscale

A Tumor-targeting and Mitochondria-anchorable Probe for NIR/MRI Imaging-guided Photodynamic Therapy of Colorectal Cancer

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Key Points

This study aims to develop a novel theranostic probe that targets tumors and anchors to mitochondria for better phototherapy outcomes.
Designed and synthesized a specific tumor-targeting and mitochondria-anchorable probe.
Evaluated the effectiveness of the probe in NIR/MRI imaging-guided photodynamic therapy.
The probe showed significant tumor targeting and accumulation in mitochondrial sites, improving treatment efficacy.
Enhanced imaging capabilities allowed for precise monitoring of the therapy response.

Implication

Demonstrates improved imaging-guided therapy in colorectal cancer, suggesting enhanced treatment efficiency.

Abstract

Phototherapy is one of important therapeutic modalities for tumor treatment. However, traditional phototherapy still faces huge challenges in clinics. Herein, we rationally design and synthesize a tumor-targeting and mitochondria-anchorable theranostic...

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Cite This Study

Cui et al. (2026) studied this question.

synapsesocial.com/papers/6a1fc4bbdee9eb8c0dce636a https://doi.org/10.1039/d6nr01015f

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A Tumor-targeting and Mitochondria-anchorable Probe for NIR/MRI Imaging-guided Photodynamic Therapy of Colorectal Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

A Tumor-targeting and Mitochondria-anchorable Probe for NIR/MRI Imaging-guided Photodynamic Therapy of Colorectal Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

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