What question did this study set out to answer?

The aim is to develop mitochondria-targeted organic probes for enhanced photodynamic therapy in cancer.

March 5, 2026

Mitochondria-Targeted NIR-II Organic Probes for Imaging–Guided Photodynamic Therapy

HZHui ZhouShanghai Institute of Technical Physics YJYuquan JiNanjing University of Posts and Telecommunications SYSiyang YuNanjing University of Posts and Telecommunications

Key Points

The aim is to develop mitochondria-targeted organic probes for enhanced photodynamic therapy in cancer.
Developed organic probes for NIR-II fluorescence imaging.
Evaluated imaging capabilities in tumor tissues.
Assessed the effectiveness of photodynamic therapy using these probes.
Probes demonstrated superior tumor imaging with enhanced penetration over traditional photosensitizers.
Achieved effective photodynamic therapy with reduced side effects in targeted areas.

Abstract

Fluorescence imaging–guided photodynamic therapy (PDT) is a compelling modality for precision cancer treatment, yet most organic photosensitizers emitting in the visible or first near-infrared (NIR-I) region suffer from limited penetration,...

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