What does this research mean for the field?

Reduced systolic and diastolic nocturnal blood pressure decline rates are independently associated with an increased risk of coronary slow flow phenomenon in hypertensive patients. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research investigates the link between blood pressure patterns and coronary slow flow in hypertensive patients without significant blockages.

June 3, 2026

Reduced Nocturnal Blood Pressure Decline Rate Is Associated With Coronary Slow Flow in Hypertensive Patients

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Hypertension without significant coronary stenosis (n=275). Intervention: Reduced nocturnal blood pressure decline rate (non-dipper, reverse-dipper, extreme dipper patterns) vs. Dipper pattern. Primary outcome: Coronary slow flow phenomenon (CSFP).

Key Result

Reduced nocturnal blood pressure decline rates were independently associated with a higher risk of coronary slow flow phenomenon compared to the normal dipper pattern.

Key Points

This research investigates the link between blood pressure patterns and coronary slow flow in hypertensive patients without significant blockages.
275 patients undergoing coronary angiography were categorized based on nocturnal blood pressure patterns.
Clinical data, angiography findings, and ambulatory blood pressure parameters were analyzed.
Logistic regression and linear correlation analyses were conducted to assess relationships.
Patients with non-dipper, reverse-dipper, and extreme dipper patterns had a higher risk of coronary slow flow than the dipper group.
Coronary TIMI frame count was negatively correlated with systolic and diastolic nocturnal blood pressure decline rates.
Both systolic and diastolic nocturnal blood pressure decline rates were independently associated with coronary slow flow phenomenon.

Study Design

Type

Observational (n=275)

Structured PICO

Is abnormal nocturnal blood pressure decline rate associated with coronary slow flow phenomenon in hypertensive patients without significant coronary stenosis?

Population

275 hypertensive patients without significant coronary stenosis undergoing coronary angiography.

Exposure

Abnormal blood pressure circadian rhythm (reverse-dipper, non-dipper, extreme dipper based on nocturnal blood pressure decline rate)

Comparator

Normal blood pressure circadian rhythm (dipper)

Outcome

Coronary slow flow phenomenon (CSFP) and coronary TIMI frame countsurrogate

Reduced nocturnal blood pressure decline is independently associated with coronary slow flow phenomenon in hypertensive patients, suggesting a role for ambulatory BP monitoring in assessing CSFP risk.

Abstract

Objective: This study investigated the correlation between blood pressure circadian rhythm and coronary slow flow phenomenon (CSFP) in hypertensive patients without significant coronary stenosis. Design and method: A total of 275 patients undergoing coronary angiography were categorized into four groups (dipper, reverse-dipper, non-dipper, extreme dipper) based on nocturnal blood pressure decline rate. Clinical data, angiography findings, and ambulatory blood pressure monitoring parameters were analyzed and compared. Logistic regression and linear correlation/regression analyses were employed. Results: Compared to the dipper group, patients with other circadian patterns had a higher risk of CSFP. Coronary TIMI frame count was negatively correlated with both systolic and diastolic nocturnal BP decline rates. Linear regression confirmed both Nocturnal SBP and DBP Decline Rates were independently associated with CSFP. Conclusions: Both systolic and diastolic nocturnal blood pressure decline rates are independently associated with coronary slow flow phenomenon. Ambulatory blood pressure monitoring may aid in monitoring CSFP risk in hypertensive patients.

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Cite This Study

Di et al. (Fri,) conducted a observational in Hypertension without significant coronary stenosis (n=275). Reduced nocturnal blood pressure decline rate (non-dipper, reverse-dipper, extreme dipper patterns) vs. Dipper pattern was evaluated on Coronary slow flow phenomenon (CSFP). Reduced nocturnal blood pressure decline rates were independently associated with a higher risk of coronary slow flow phenomenon compared to the normal dipper pattern.

synapsesocial.com/papers/6a1fc56bdee9eb8c0dce6d9b https://doi.org/https://doi.org/10.1097/01.hjh.0001197216.85413.b5

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