Non-dipper hypertension was associated with similar coronary flow reserve compared to dipper hypertension (2.47 vs 2.39) in patients without excessive left ventricular hypertrophy.
Observational (n=37)
Does non-dipping blood pressure affect coronary flow reserve in hypertensive patients without other cardiovascular risk factors?
In hypertensive patients without excessive left ventricular hypertrophy or other cardiovascular risk factors, non-dipping blood pressure does not significantly impair coronary flow reserve compared to dippers.
Absolute Event Rate: 2.47% vs 2.39%
BACKGROUND: Failure to decrease blood pressure (BP) normally during night-time, which is called non-dipping, in hypertensive individuals is associated with higher cardiovascular morbidity and mortality. In addition, non-dipping BP leads to structural changes in the left ventricle; however, the effect of non-dipping BP on coronary flow reserve (CFR) has not been studied yet. METHODS: In this study, we measured CFR of 22 subjects with non-dipper hypertension, and 15 subjects with dipper hypertension using transthoracic second-harmonic Doppler echocardiography (Acuson Sequoia C256. None of the subjects had any systemic disease or coronary risk factor except hypertension. RESULTS: Age, gender, body mass index, lipids and echocardiographic findings including left ventricular mass index were similar between the groups. Office BP recordings were similar between non-dipper and dipper groups (147.9+/-6.1/93.9+/-4.3 vs 144.0+/-8.0/93.0+/-3.7). Daytime and 24-h ambulatory BP measurements were similar within the groups, but night-time BPs were significantly greater in non-dipper group than those were in dipper group. Left ventricular diastolic and systolic functions, and both baseline and hyperemic peak diastolic coronary velocity as well as CFR, were similar between the non-dipper and dipper groups (CFR: 2.47+/-0.59 vs 2.39+/-0.47). CONCLUSION: CFR were similar in patients with non-dipper and dipper hypertension in the absence of excessive left ventricular hypertrophy and other cardiovascular risk factors.
Erdoğan et al. (Sat,) conducted a observational in Hypertension (n=37). Non-dipper hypertension vs. Dipper hypertension was evaluated on Coronary flow reserve (CFR). Non-dipper hypertension was associated with similar coronary flow reserve compared to dipper hypertension (2.47 vs 2.39) in patients without excessive left ventricular hypertrophy.
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