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October 1, 1989Journal of Biological ChemistryOpen Access

In rat hypothalamus, approximately equimolar amounts of Ang-(1-7), Ang-II, and Ang-I were detected (1.10, 1.18, and 1.45 pmol/g of tissue, respectively), demonstrating the endogenous presence of Ang-(1-7).

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Population

Rat tissues (brain, adrenal gland, and plasma)

Design

Preclinical

Authors

MCMark C. ChappellHeart Failure & TransplantKBK. Bridget BrosnihanAtrium Health Wake Forest BaptistDDDebra I. DizVascular Medicine

Discussion

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Overview

Does not yet inform clinical RAS modulation; leaves open Ang-(1-7) tissue actions in human cardiovascular regulation.

Structured PICO

P
Population
Rat tissues (brain, adrenal gland, and plasma)
I
Intervention
Characterization of angiotensin (Ang) peptides by reverse-phase high performance liquid chromatography and three specific radioimmunoassays
O
Outcome
Distribution and levels of Ang peptides (Ang-(1-7), Ang-II, and Ang-I) in tissues and plasmasurrogate

This study provides the first demonstration of the endogenous presence of Ang-(1-7) in central and peripheral tissues of the rat, suggesting tissue-specific processing of angiotensins.

Cite This Study

Chappell et al. (1989) studied this question.

synapsesocial.com/papers/6a209de748884d7e56911827https://doi.org/10.1016/s0021-9258(19)84737-3
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