The balance between nitric oxide and superoxide is more important than the absolute levels of either alone in the context of hypertension and cardiovascular disease.
In hypertension, the balance between nitric oxide and superoxide is a more critical determinant of endothelial function than the absolute levels of either molecule.
Much attention has been focused on the role of nitric oxide in hypertension and cardiovascular disease. More recently, the role of superoxide anion and its interaction with nitric oxide has been investigated in this context. This review will concentrate on the role of superoxide in human and experimental hypertension, paying particular attention to the potential sources of superoxide within the vasculature and discussing some of the molecular mechanisms surrounding its production and dismutation. We discuss what is known about the human superoxide dismutase enzymes. We conclude that the balance between nitric oxide and superoxide is more important than the absolute levels of either alone.
McIntyre et al. (Fri,) conducted a review in Hypertension and cardiovascular disease. The balance between nitric oxide and superoxide is more important than the absolute levels of either alone in the context of hypertension and cardiovascular disease.