Endothelial Function in Hypertension
Key result
The balance between nitric oxide and superoxide is more important than the absolute levels of either alone in the context of hypertension and cardiovascular disease.
Population
Human and experimental hypertension models
Design
Review
Authors
Discussion
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Implication
Hypothesis-generating for redox-targeted hypertension therapies; prospective trials needed before clinical adoption.
Structured PICO
P
Population
Human and experimental hypertension models
In hypertension, the balance between nitric oxide and superoxide is a more critical determinant of endothelial function than the absolute levels of either molecule.
Cite This Study
McIntyre et al. (1999) conducted a review in Hypertension and cardiovascular disease. The balance between nitric oxide and superoxide is more important than the absolute levels of either alone in the context of hypertension and cardiovascular disease.