Patients who maintained sinus rhythm 30 days after electrical cardioversion had a 62.0% reduction in NT-proBNP levels, compared to a 1.1% increase in those with recurrent atrial fibrillation.
Cohort (n=100)
Are changes in biomarker levels (BMP10, NT-proBNP) associated with rhythm status at 30 days after electrical cardioversion in patients with persistent atrial fibrillation?
Changes in BMP10 and NT-proBNP levels are independently associated with rhythm status 30 days after cardioversion, suggesting these biomarkers reflect actual heart rhythm rather than just baseline cardiovascular risk.
Mean Difference: -63.1 (95% CI -76.6–-49.6)
Absolute Event Rate: -62% vs 1.1%
p-value: p=<0.001
Biomarkers may help to improve our knowledge about the complex pathophysiology of atrial fibrillation (AF). In this study we sought to identify significant changes in biomarkers and clinical measures in patients with and without AF recurrence after electrical cardioversion. We measured 21 conventional and new biomarkers before and 30 days after electrical cardioversion and assessed the associations of changes in biomarker levels with rhythm status at follow-up. Significant between-group changes were observed for bone morphogenetic protein 10 (BMP10), N-terminal pro-B-type natriuretic peptide (NT-proBNP) and total bilirubin. Their respective changes were - 10.4%, - 62.0% and - 25.6% in patients with sinus rhythm, and 3.1%, 1.1% and - 9.4% in patients with recurrent AF, for a between-group difference of - 13.5% (95% confidence interval CI - 19.3% to - 7.6%; P < 0.001), - 63.1% (95% CI - 76.6% to - 49.6%; P < 0.001) and - 16.3% (95% CI - 27.9% to - 4.7%; P = 0.007). In multivariable models, the reductions of BMP10 and NT-proBNP were significantly associated with follow-up rhythm status (β coefficient per 1 - SD decrease, - 3.85; 95% CI - 6.34 to - 1.35; P = 0.003 for BMP10 and - 5.84; 95% CI - 10.22 to - 1.47; P = 0.009 for NT-proBNP. In conclusion, changes in BMP10 und NT-proBNP levels were independently associated with rhythm status after cardioversion, suggesting that these markers may be dependent on the actual heart rhythm.
Meyre et al. (Mon,) conducted a cohort in Persistent atrial fibrillation (n=100). Sinus rhythm after electrical cardioversion vs. Atrial fibrillation recurrence was evaluated on Percent change in NT-proBNP levels at 30 days (MD -63.1%, 95% CI -76.6 to -49.6, p=<0.001). Patients who maintained sinus rhythm 30 days after electrical cardioversion had a 62.0% reduction in NT-proBNP levels, compared to a 1.1% increase in those with recurrent atrial fibrillation.