Key result
Patients who maintained sinus rhythm 30 days after electrical cardioversion had a 62.0% reduction in NT-proBNP levels, compared to a 1.1% increase in those with recurrent atrial fibrillation.
Why the study?
Biomarkers may improve understanding of the complex pathophysiology of AF, prompting investigation into biomarker changes in patients with and without AF recurrence after electrical cardioversion.
Are changes in biomarker levels (BMP10, NT-proBNP) associated with rhythm status at 30 days after electrical cardioversion in patients with persistent atrial fibrillation?
Cohort (n=100)
Are changes in biomarker levels (BMP10, NT-proBNP) associated with rhythm status at 30 days after electrical cardioversion in patients with persistent atrial fibrillation?
Mean Difference: -63.1 (95% CI -76.6–-49.6)
Absolute Event Rate: -62% vs 1.1%
p-value: p=<0.001
Changes in BMP10 and NT-proBNP levels are independently associated with rhythm status 30 days after cardioversion, suggesting these biomarkers reflect actual heart rhythm rather than just baseline cardiovascular risk.
NT-proBNP reduction tracks sinus rhythm maintenance after cardioversion; hypothesis-generating for biomarker monitoring in persistent AF, needs prospective validation.
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Meyre et al. (2022) conducted a cohort in Persistent atrial fibrillation (n=100). Sinus rhythm after electrical cardioversion vs. Atrial fibrillation recurrence was evaluated on Percent change in NT-proBNP levels at 30 days (MD -63.1%, 95% CI -76.6 to -49.6, p=<0.001). Patients who maintained sinus rhythm 30 days after electrical cardioversion had a 62.0% reduction in NT-proBNP levels, compared to a 1.1% increase in those with recurrent atrial fibrillation.
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