Patients with metabolic syndrome had significantly lower left (3.2 vs 4.0; p<0.001) and right (2.6 vs 3.1; p=0.001) ventricular isovolumic myocardial acceleration compared to controls.
Case-Control (n=133)
Does metabolic syndrome lead to subclinical left and right ventricular systolic dysfunction as measured by isovolumic acceleration?
Metabolic syndrome is associated with impaired subclinical global, diastolic, and systolic biventricular function, detectable by reduced isovolumic myocardial acceleration on tissue Doppler imaging.
Absolute Event Rate: 3.2% vs 4%
p-value: p=<0.001
OBJECTIVE: The aim of this study was to assess subclinical left (LV) and right ventricular (RV) dysfunction novel load-independent isovolumic myocardial acceleration (IVA) derived from tissue Doppler imaging (TDI) in patient with metabolic syndrome (MetS). METHODS: This study had an observational case-control design. The study included 133 subjects which were divided into two groups: 75 patients with MetS and 58 controls without MetS. MetS was defined by the presence of ≥3 criteria according to ATP-NCEP III guidelines. All the subjects underwent laboratory blood tests and complete conventional echocardiography and TDI. Student's t, Mann-Whitney U, Pearson's, and multiple regression analysis were used for statistical analysis. RESULTS: There were no significant difference between two groups in terms of traditional echocardiographic parameters. The diastolic and global functions of both ventricles were significantly impaired in MetS group. The TDI-derived IVA of the LV and the RV was significantly lower in patients with MetS (3.2±0.9 vs. 4.0±1.4, p<0.001 and 2.6±0.7 vs. 3.1±0.9, p=0.001, respectively). Whereas, TDI derived systolic velocity (Sa), and peak myocardial velocity during isovolumic contraction (IVV) of both ventricles were similar between the two groups. In the multiple regression analysis, waist circumference and diastolic blood pressure were found to be an independent determinant of IVA of LV (b=-.223, 95% CI=-.034 -.002, p=0.004) and RV (b=-.527, 95% CI=-.085 -.020, p=0.002) respectively. CONCLUSION: MetS affects global, diastolic, and systolic functions of two ventricles. This disruption lead to decreased function of heart was related with raised risk factors of MetS.
Ertürk et al. (Sun,) conducted a case-control in Metabolic syndrome (n=133). Metabolic syndrome vs. Controls without metabolic syndrome was evaluated on Tissue Doppler imaging-derived isovolumic myocardial acceleration (IVA) of the left ventricle (p=<0.001). Patients with metabolic syndrome had significantly lower left (3.2 vs 4.0; p<0.001) and right (2.6 vs 3.1; p=0.001) ventricular isovolumic myocardial acceleration compared to controls.
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