Does fresh-frozen plasma prevent hematoma progression in patients with warfarin-associated intracerebral hemorrhage?
FFP administration for warfarin-associated ICH is associated with significant delays to INR normalization and may not prevent hematoma progression.
To identify hematoma progression in patients with warfarin-associated intracerebral hemorrhage (ICH) despite international normalized ratio (INR) normalization with fresh-frozen plasma (FFP), we reviewed 45 patients with warfarin-associated ICH given FFP. The median time for door to INR normalization was 30 hours (14 to 49.5), with 4 patients' hematomas enlarging after INR normalization. FFP is associated with substantial time delay to actual administration and pulmonary edema and may not prevent progression of ICH despite INR normalization.
Lee et al. (Mon,) studied this question.
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