Why the study?
Does fresh-frozen plasma prevent hematoma progression in patients with warfarin-associated intracerebral hemorrhage?
Does fresh-frozen plasma prevent hematoma progression in patients with warfarin-associated intracerebral hemorrhage?
FFP administration for warfarin-associated ICH is associated with significant delays to INR normalization and may not prevent hematoma progression.
Significant delays to INR normalization with FFP and post-normalization expansion warrant caution; leaves open whether FFP prevents progression in warfarin-associated ICH.
To identify hematoma progression in patients with warfarin-associated intracerebral hemorrhage (ICH) despite international normalized ratio (INR) normalization with fresh-frozen plasma (FFP), we reviewed 45 patients with warfarin-associated ICH given FFP. The median time for door to INR normalization was 30 hours (14 to 49.5), with 4 patients' hematomas enlarging after INR normalization. FFP is associated with substantial time delay to actual administration and pulmonary edema and may not prevent progression of ICH despite INR normalization.
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Lee et al. (2006) studied this question.
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