What question did this study set out to answer?

To compare the efficacy of fresh frozen plasma versus clotting factor concentrates in rapidly correcting coagulopathy and restoring clotting factor levels in patients taking oral anticoagulants.

January 1, 1997Thrombosis and Haemostasis

Emergency Oral Anticoagulant Reversal: The Relative Efficacy of Infusions of Fresh Frozen Plasma and Clotting Factor Concentrate on Correction of the Coagulopathy

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Why the study?

Do clotting factor concentrates improve INR correction compared to fresh frozen plasma in orally anticoagulated patients requiring rapid reversal?

Population

41 orally anticoagulated subjects requiring rapid correction of their haemostatic defect

Comparison

Clotting factor concentrates vs Fresh frozen plasma (FFP)

Design

Cohort

Authors

MGM. GreavesUniversity of Aberdeen WPWendy PhillipsMississippi State University SKSteve KitchenUniversity of Sheffield

Discussion

Member takes

Implication

Clotting factor concentrates were associated with superior INR correction versus FFP; leaves open whether randomized trials confirm clinical outcome benefits.

Key Points

To compare the efficacy of fresh frozen plasma versus clotting factor concentrates in rapidly correcting coagulopathy and restoring clotting factor levels in patients taking oral anticoagulants.
Evaluated orally anticoagulated patients requiring emergency reversal of excessive anticoagulation and bleeding risk.
Administered either fresh frozen plasma (N=12) or clotting factor concentrates (N=29) and monitored post-treatment INR alongside vitamin K-dependent clotting factor levels.
INR completely corrected in 28 of 29 patients (96.6%) receiving clotting factor concentrates (mean post-treatment INR 1.3, range 0.9–3.8), whereas 0 of 12 patients receiving fresh frozen plasma achieved full correction (mean post-treatment INR 2.3, range 1.6–3.8).
Post-treatment median factor IX levels reached 68.5 u/dl (range 31–111) in the concentrate group compared to 19 u/dl (range 10–63) in the fresh frozen plasma group.

Structured PICO

Do clotting factor concentrates improve INR correction compared to fresh frozen plasma in orally anticoagulated patients requiring rapid reversal?

Population

41 orally anticoagulated subjects requiring rapid correction of their haemostatic defect (e.g., due to haemorrhage or dangerously high INR)

Intervention

Clotting factor concentrates

Comparator

Fresh frozen plasma (FFP)

Outcome

Correction of International Normalized Ratio (INR) and clotting factor levels (specifically factor IX)surrogate

Clotting factor concentrates are significantly more effective than fresh frozen plasma for achieving complete and immediate correction of coagulopathy in patients requiring rapid reversal of oral anticoagulation.

Cite This Study

Greaves et al. (1997) studied this question.

synapsesocial.com/papers/6a7cb40cfd7ae2306b771260 https://doi.org/10.1055/s-0038-1655992

Topics

Anticoagulation in AF

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Implication

Clotting factor concentrates were associated with superior INR correction versus FFP; leaves open whether randomized trials confirm clinical outcome benefits.

Emergency Oral Anticoagulant Reversal: The Relative Efficacy of Infusions of Fresh Frozen Plasma and Clotting Factor Concentrate on Correction of the Coagulopathy

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Emergency Oral Anticoagulant Reversal: The Relative Efficacy of Infusions of Fresh Frozen Plasma and Clotting Factor Concentrate on Correction of the Coagulopathy

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider