Key result
Prothrombin complex concentrates were more effective than fresh frozen plasma in shortening the time to INR correction for warfarin reversal, with a low risk of thrombotic adverse events.
Why the study?
Do prothrombin complex concentrates improve time to INR correction compared to fresh frozen plasma in patients with warfarin over-anticoagulation?
Do prothrombin complex concentrates improve time to INR correction compared to fresh frozen plasma in patients with warfarin over-anticoagulation?
This review suggests that prothrombin complex concentrates offer a rapid and specific method for reversing warfarin anticoagulation, shortening time to INR correction compared to fresh frozen plasma.
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PCCs may shorten INR correction time vs FFP with low thrombotic risk; leaves open need for prospective trials and guidelines.
Leissinger et al. (2007) conducted a review in Over-anticoagulation with warfarin therapy. Prothrombin complex concentrates (PCCs) vs. Fresh frozen plasma (FFP) was evaluated on Time to INR correction and risk of thrombotic adverse events. Prothrombin complex concentrates were more effective than fresh frozen plasma in shortening the time to INR correction for warfarin reversal, with a low risk of thrombotic adverse events.
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