Key result
Fixed dose prothrombin complex concentrate (Beriplex) was successfully used for warfarin reversal, though randomized controlled trials are needed to determine the ideal dose.
Why the study?
Does fixed dose prothrombin complex concentrate (PCC) provide rapid reversal of warfarin with minimum risk of thrombosis in patients requiring warfarin reversal?
Does fixed dose prothrombin complex concentrate (PCC) provide rapid reversal of warfarin with minimum risk of thrombosis in patients requiring warfarin reversal?
Answers are grounded in this paper and cite their sources.
While fixed-dose PCC is used clinically for warfarin reversal, randomized trials are needed to establish the optimal dosing strategy.
Warfarin reversal is frequently required in day to day haematology practice. Prothrombin complex concentrates (PCC) have replaced fresh frozen plasma as the agent of choice in warfarin reversal due to its safety profile. Ideal dose of PCC is still not known and many centres have local guidelines on using the product. We have successfully used PCC (Beriplex) at a fixed dose in our hospital, but we still need randomised control trials to identify the ideal dose of PCC which can result in rapid reversal of warfarin with minimum risk of thrombosis.
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Junagade et al. (2007) studied Warfarin reversal. Prothrombin complex concentrate (Beriplex) was evaluated. Fixed dose prothrombin complex concentrate (Beriplex) was successfully used for warfarin reversal, though randomized controlled trials are needed to determine the ideal dose.
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