Key result
Emergent warfarin reversal protocols at international clinical sites varied, with 53% using prothrombin complex concentrate (PCC), 25% using PCC plus plasma, and 2% using plasma alone.
Why the study?
What are the current international hospital protocols for emergent reversal of warfarin?
Cross-Sectional
Yes
What are the current international hospital protocols for emergent reversal of warfarin?
Despite international guidelines recommending four-factor prothrombin complex concentrates for emergent warfarin reversal, there remains significant variation in real-world hospital protocols regarding product choice and dosing strategies.
Practice variation in 4FPCC dosing for warfarin reversal persists; leaves open standardization of fixed versus adjusted regimens.
For emergent warfarin reversal, four-factor prothrombin complex concentrates (4FPCCs) are recommended by many international guidelines. We surveyed international clinical sites including members of the Biomedical Excellence for Safer Transfusion (BEST) Collaborative. Most sites have emergent warfarin reversal protocols (53% use PCC, 25% use PCC+ plasma and 2% use plasma alone); however, variation between adjusted dosing and fixed dosing was observed.
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Gorlin et al. (2017) conducted a cross-sectional in emergent warfarin reversal. emergent warfarin reversal protocols was evaluated on protocol type. Emergent warfarin reversal protocols at international clinical sites varied, with 53% using prothrombin complex concentrate (PCC), 25% using PCC plus plasma, and 2% using plasma alone.
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