April 26, 2004Archives of Internal Medicine
The Effect of Warfarin and Intensity of Anticoagulation on Outcome of Intracerebral Hemorrhage
Why the study?
Does warfarin use at the time of intracerebral hemorrhage increase 3-month mortality in patients aged 55 years or older?
Population
435 consecutive patients aged 55 years or older with supratentorial intracerebral hemorrhage treated in a…
Comparison
Warfarin use at the time of intracerebral… vs No warfarin use at the time of intracerebral…
Design
Cohort
Follow-up
3 months
Authors
Discussion
Loading...
Member takes
Implication
May heighten caution prescribing warfarin to ICH-prone elderly; leaves open whether alternatives or tighter INR control improve survival.
Structured PICO
Does warfarin use at the time of intracerebral hemorrhage increase 3-month mortality in patients aged 55 years or older?
P
Population
435 consecutive patients aged 55 years or older with supratentorial intracerebral hemorrhage (ICH) treated in a tertiary care hospital with a neurointensive care unit.
I
Intervention
Warfarin use at the time of intracerebral hemorrhage
C
Comparator
No warfarin use at the time of intracerebral hemorrhage
O
Outcome
3-month mortalityhard clinical
Warfarin use at the time of intracerebral hemorrhage independently doubles the risk of 3-month mortality in a dose-dependent manner.
Cite This Study
Rosand et al. (2004) studied this question.