Occlusion of the main atrial arteries in dogs significantly prolonged the spontaneous cycle length from 335 ms to 416 ms at 1 hour (p<0.005) and induced ischemic sinus node dysfunctions.
Absolute Event Rate: 416% vs 335%
p-value: p=<0.005
The effects of the occlusion of the two main atrial arteries irrigating the sinus node on sinus rhythm and postpacing sinus recovery were studied in 12 anesthetized dogs. Records of spontaneous rhythm and of postpacing sinus recovery were taken at control and hourly for 6 hours after the occlusion. The spontaneous cycle length (AA interval) was 335 +/- 11 ms at control and 416 +/- 17 ms (mean +/- SE) (p less than 0.005) one hour after the occlusion. It remained nearly unchanged during the following 5 hours of observation. The occlusion also shortened atrioventricular conduction time (AV interval) and reduced P-wave amplitude in ECG lead II in 9 of these dogs. While the control postpacing sinus recovery time was 397 +/- 13 ms, the 1-hour value was 715 +/- 165 ms. This prolongation persisted during the first four postocclusion hours but was less marked during the last two hours of observation. Moreover, the postpacing mode of return of the AA intervals to their prepacing value (sinus recovery pattern) became characteristically slow and progressive after occlusion, complete postpacing recovery often occurring only after 100 or more beats. Sequences of escape atrial and/or AV junctional rhythms were frequently seen during this recovery. Atrial extrasystoles and short sequences of atrial tachycardias were observed in most dogs after occlusion. Conversely, none of these changes occurred during a 6-hour experimental time in 5 control dogs in which the same protocol, occlusion excepted, was repeated. These observations show that the sinus node function in the dog is consistently affected by impairing its blood supply. Ischemic dysfunctions include sinus slowing, pacemaker shift, prolonged sinus recovery time, delayed postpacing recovery and supraventricular tachyarrhythmias.
Billette et al. (Sat,) conducted a other in Acute Ischemic Sinus Node Dysfunctions (n=17). Occlusion of the two main atrial arteries irrigating the sinus node vs. No occlusion (control dogs) and baseline control was evaluated on Spontaneous cycle length (AA interval) at 1 hour (p=<0.005). Occlusion of the main atrial arteries in dogs significantly prolonged the spontaneous cycle length from 335 ms to 416 ms at 1 hour (p<0.005) and induced ischemic sinus node dysfunctions.