Key result
Occlusion of the main atrial arteries in dogs significantly prolonged the spontaneous cycle length from 335 ms to 416 ms at 1 hour (p<0.005) and induced ischemic sinus node dysfunctions.
Why the study?
Does occlusion of the main atrial arteries irrigating the sinus node affect sinus rhythm and postpacing sinus recovery in dogs?
Does occlusion of the main atrial arteries irrigating the sinus node affect sinus rhythm and postpacing sinus recovery in dogs?
Absolute Event Rate: 416% vs 335%
p-value: p=<0.005
Impairing blood supply to the sinus node in dogs consistently causes ischemic dysfunctions including sinus slowing, prolonged sinus recovery time, and supraventricular tachyarrhythmias.
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May model ischemic sinus node dysfunction; leaves open human translation and clinical relevance.
Billette et al. (1978) studied Acute Ischemic Sinus Node Dysfunctions (n=17). Occlusion of the two main atrial arteries irrigating the sinus node vs. No occlusion (control dogs) and baseline control was evaluated on Spontaneous cycle length (AA interval) at 1 hour (p=<0.005). Occlusion of the main atrial arteries in dogs significantly prolonged the spontaneous cycle length from 335 ms to 416 ms at 1 hour (p<0.005) and induced ischemic sinus node dysfunctions.
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