Lactate concentrations in coronary veins within ischaemic myocardium were three to four times higher than in veins nearer to the coronary vein up to 2.5 hours after LAD ligation in dogs.
Effect estimate: 3 to 4 times higher
Lacate concentrations were measured in blood from (a) coronary veins within ischaemic myocardium and (b) veins nearer to the coronary vein, for periods of up to 2 1/2 hours after ligation of the left anterior descending artery in dogs. Concentrations at (a) were three to four times higher than at (b), while blood sampled simultaneously from two veins at (a) yielded similar concentrations of lactate. At 2 1/2 hours after ligation the veno-arterial difference of lactate concentration in blood from (a) was about one half of the difference at 15 minutes. Lactate concentration at (a) was approximately twice as great when the area of ischaemic myocardium drained by the vein was large (18 not equal to 1% of heart weight) than when it was small (6 not equal to 1% of heart weight). No close correlation was apparent between the height of epicardial ST-segment elevation and the level of lactate release. These experiments extend previous observations that changes in lactate concentration at a given site may reflect changes in venous dilution, rather than in the rate of production of lactate, and emphasize that caution is necessary in interpretation of changes in concentrations of metabolites in coronary sinus blood after acute myocardial infarction in man.
Smith et al. (Sun,) conducted a other in Experimental myocardial infarction. Blood sampling from coronary veins within ischaemic myocardium vs. Blood sampling from veins nearer to the coronary vein was evaluated on Lactate concentration (3 to 4 times higher). Lactate concentrations in coronary veins within ischaemic myocardium were three to four times higher than in veins nearer to the coronary vein up to 2.5 hours after LAD ligation in dogs.