Key result
Lactate concentrations in coronary veins within ischaemic myocardium were three to four times higher than in veins nearer to the coronary vein up to 2.5 hours after LAD ligation in dogs.
Why the study?
Does the site of venous blood sampling affect measured lactate concentrations after experimental myocardial infarction in dogs?
Does the site of venous blood sampling affect measured lactate concentrations after experimental myocardial infarction in dogs?
Effect estimate: 3 to 4 times higher
The study demonstrates that regional differences in venous sampling sites significantly affect measured lactate concentrations after MI, highlighting the confounding effect of venous dilution.
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Sampling site confounds lactate measurements in canine MI models; leaves open translation to human coronary venous sampling.
Smith et al. (1976) studied Experimental myocardial infarction. Blood sampling from coronary veins within ischaemic myocardium vs. Blood sampling from veins nearer to the coronary vein was evaluated on Lactate concentration (3 to 4 times higher). Lactate concentrations in coronary veins within ischaemic myocardium were three to four times higher than in veins nearer to the coronary vein up to 2.5 hours after LAD ligation in dogs.
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