Key result
Graded coronary ischemia in swine significantly increased regional myocardial lactate release from 0.15 to 1.19 μmols/ml (p<0.003), inversely correlating with subendocardial blood flow.
Population
9 open-chest swine
Comparison
Graded coronary ischemia in the left anterior… vs Control state (baseline before ischemia)
Design
Preclinical
Authors
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Lactate release tracks subendocardial ischemia in swine models; leaves open clinical translation for human biomarker use.
Absolute Event Rate: 1.19% vs 0.15%
p-value: p=<0.003
In a swine model, regional myocardial lactate release is closely and inversely correlated with regional subendocardial blood flow during graded ischemia.
Guth et al. (1990) studied Regional myocardial ischemia (n=9). Graded coronary ischemia vs. Control (baseline) was evaluated on Regional myocardial lactate release (mumols/ml) (p=<0.003). Graded coronary ischemia in swine significantly increased regional myocardial lactate release from 0.15 to 1.19 μmols/ml (p<0.003), inversely correlating with subendocardial blood flow.
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