Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 1, 1973European Journal of Clinical Investigation

Relative Rates of Oxidation of Glucose and Free Fatty Acids by Ischaemic and Non‐Ischaemic Myocardium after Coronary Artery Ligation in the Dog*

View Full Paper
Ask AI
Bookmark
Share

Population

Greyhound dogs with small regional ischemic lesions produced by ligation of a branch of the anterior…

Comparison

Ligation of a branch of the anterior descending… vs Non-ischemic myocardium

Design

Preclinical

Follow-up

Up to 120 minutes post-ligation

Authors

LOLionel H. OpiePOPatrica OwenRRRudolph A. Riemersma

Discussion

Loading...

Member takes

Overview

Should not change clinical ischemia management; hypothesis-generating for substrate shifts, needing human validation.

Structured PICO

P
Population
Greyhound dogs with small regional ischemic lesions (about 7% of whole heart volume) produced by ligation of a branch of the anterior descending coronary artery.
I
Intervention
Ligation of a branch of the anterior descending coronary artery
C
Comparator
Non-ischemic myocardium (assessed via coronary sinus samples)
O
Outcome
Relative rates of oxidation of glucose and free fatty acids (FFA) assessed by oxygen extraction ratio and 14CO2 formationsurrogate

In a canine model of myocardial ischemia, both anaerobic and aerobic metabolism of glucose are accelerated relative to free fatty acid oxidation.

Cite This Study

Opie et al. (1973) studied this question.

synapsesocial.com/papers/6a6fe814febe604dd708bafahttps://doi.org/10.1111/j.1365-2362.1973.tb02210.x
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Metabolic Response during Impending Myocardial Infarction1972 · 79 citations
  2. 2Free fatty acid metabolism of the human heart at rest1969 · 81 citations
  3. 3Myocardial Lipid and Carbohydrate Metabolism in Healthy, Fasting Men at Rest: Studies During Continuous Infusion of <sup>3</sup>H‐Palmitate1972 · 80 citations
  4. 4The Role of Free Fatty Acids in the Production of Ventricular Arrhythmias after Acute Coronary Artery Occlusion1971 · 190 citations
  5. 5The Lipid Composition of Mitochondrial and Microsomal Fractions of Human Myocardial Homogenates1969 · 27 citations