What does this research mean for the field?

Coronary artery occlusion reduces regional myocardial blood flow and oxygen consumption while increasing oxygen extraction, with marked microvascular heterogeneity throughout the ischemic zone. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 1, 1980Circulation ResearchOpen Access

Effect of coronary artery occlusion on regional arterial and venous O2 saturation, O2 extraction, blood flow, and O2 consumption in the dog heart.

Q: What is the clinical evidence from this study?

Study design: Other. Population: Coronary artery occlusion (n=14). Intervention: Coronary artery occlusion vs. Unoccluded areas (control area). Primary outcome: Regional blood flow, oxygen extraction, and oxygen consumption.

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Key result

Canine coronary occlusion reduces regional blood flow and oxygen consumption while increasing oxygen extraction.

n=14

Population

14 anesthetized open-chest dogs

Comparison

Coronary artery occlusion vs Unoccluded areas of the same hearts

Design

Preclinical

Follow-up

Up to 2 hours

Authors

HWHarvey R. WeissRutgers, The State University of New Jersey

Discussion

Member takes

Implication

Heterogeneity in canine ischemic zones suggests nonuniform responses; leaves open translation to human infarct assessment.

Structured PICO

Population

14 anesthetized open-chest dogs subjected to coronary artery occlusion for 10 minutes or 2 hours.

Intervention

Coronary artery occlusion (10 minutes in n=7, 2 hours in n=7)

Comparator

Unoccluded areas of the same hearts

Outcome

Regional arterial and venous O2 saturation, oxygen extraction, blood flow, and oxygen consumptionsurrogate

Coronary artery occlusion in a canine model demonstrates marked heterogeneity in regional blood flow and oxygen extraction within the ischemic area.

Cite This Study

Harvey R. Weiss (1980) studied Coronary artery occlusion (n=14). Coronary artery occlusion vs. Unoccluded areas (control area) was evaluated on Regional blood flow, oxygen extraction, and oxygen consumption. Coronary artery occlusion in dogs significantly reduced regional blood flow and oxygen consumption while increasing oxygen extraction, with marked heterogeneity within the occluded area.

synapsesocial.com/papers/6aa7b4f8ff0084718cb17fbc https://doi.org/10.1161/01.res.47.3.400

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Effect of coronary artery occlusion on regional arterial and venous O2 saturation, O2 extraction, blood flow, and O2 consumption in the dog heart.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effect of coronary artery occlusion on regional arterial and venous O2 saturation, O2 extraction, blood flow, and O2 consumption in the dog heart.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider