Why the study?
Does hypoxia alter cardiac oxygen consumption and coronary flow in anesthetized dogs?
Population
Anesthetized open-chested dogs prepared for total coronary flow measurement
Comparison
Gradual decrease in arterial O2 content (hypoxia) vs Baseline/normoxia (implied by gradual decrease)
Design
Preclinical
Authors
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Should not alter clinical hypoxia management; hypothesis-generating for human coronary autoregulation.
Does hypoxia alter cardiac oxygen consumption and coronary flow in anesthetized dogs?
In a canine model, coronary blood flow increases proportionally during hypoxia to maintain constant myocardial oxygen extraction and consumption.
Feinberg et al. (1958) studied this question.
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