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December 1, 1973Circulation Research

Effect of Arterial Hypoxia on Myocardial Oxygen Consumption

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Why the study?

Does arterial hypoxia increase myocardial oxygen consumption in adrenergically blocked dogs?

Population

18 anesthetized, adrenergically blocked dogs on right heart bypass

Comparison

Progressive decreases in arterial oxygen content vs Control level

Design

Preclinical

Authors

EPEric R. PowersUniversity of FloridaWPWilliam John PowellThe Huntington Library, Art Museum, and Botanical Gardens

Discussion

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Implication

Arterial hypoxia may raise MVO2 despite stable hemodynamics in blocked dogs; hypothesis-generating for myocardial efficiency and requires human validation.

Structured PICO

Does arterial hypoxia increase myocardial oxygen consumption in adrenergically blocked dogs?

P
Population
18 anesthetized, adrenergically blocked dogs on right heart bypass
I
Intervention
Progressive decreases in arterial oxygen content (arterial hypoxia)
C
Comparator
Control level (arterial oxygen content 15-18 ml/100 ml blood, Po2 > 200 mm Hg)
O
Outcome
Myocardial oxygen consumption (MVO2)surrogate

Arterial hypoxia increases myocardial oxygen consumption and decreases myocardial efficiency despite stable or decreased hemodynamic parameters.

Cite This Study

Powers et al. (1973) studied this question.

synapsesocial.com/papers/6a1b93ba0ea968f653abfd3dhttps://doi.org/10.1161/01.res.33.6.749
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of Hypoxia on the Myocardial Metabolism of Intact Dogs1954 · 72 citations
  2. 2Velocity of contraction as a determinant of myocardial oxygen consumption1965 · 324 citations
  3. 3Effect of free fatty acids on myocardial function and metabolism in the ischemic dog heart1972 · 165 citations
  4. 4Coronary Blood Flow and Myocardial Metabolism During Hypoxia in Adrenalectomized-Sympathectomized Dogs1956 · 20 citations
  5. 5Effects of Coronary Blood Flow and Perfusion Pressure on Left Ventricular Contractility in Dogs1970 · 120 citations