What question did this study set out to answer?

To compare blood flow and myocardial oxygen consumption between the right and left ventricles under conditions of volume overload and hypoperfusion.

January 1, 1987Japanese Circulation Journal-english EditionOpen Access

Myocardial oxygen metabolism of the right ventricle with volume loading and hypoperfusion.

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Population

Dogs with opened chests

Comparison

Volume loading by arterio-venous and… vs Baseline conditions and comparison between right…

Design

Preclinical

Authors

KTKou TakedaKagawa Prefectural Central Hospital SHShoichi HaraokaOkayama University HNHideo NagashimaKyushu University

Discussion

Member takes

Implication

RV may exhibit greater O2 extraction reserve than LV in hypoperfusion; animal findings leave open human translation.

Key Points

To compare blood flow and myocardial oxygen consumption between the right and left ventricles under conditions of volume overload and hypoperfusion.
Examined open-chest canine models under volume loading induced by arterio-venous and arterio-left atrial shunts.
Induced ventricular hypoperfusion via rapid blood withdrawal, testing hemodynamics and metabolism with the pericardium intact and open.
Baseline myocardial oxygen consumption (8.0 ± 0.6 vs. 3.5 ± 0.3 ml O2/min per 100g), coronary blood flow (75 ± 4.3 vs. 46 ± 2.8 ml/min per 100g), and oxygen extraction ratio (59 ± 2% vs. 43 ± 3%, p < 0.001) were significantly greater in the left than the right ventricle.
Hypoperfusion caused a significantly larger increase in oxygen extraction ratio in the right ventricle compared to the left ventricle (54% vs. 31%, p < 0.01).
Pericardial closure elevated bilateral end-diastolic pressures without significantly altering coronary blood flow or oxygen extraction in either ventricle.

Structured PICO

Population

Dogs with opened chests

Intervention

Volume loading by arterio-venous and arterio-left atrial shunts, and ventricular hypoperfusion by rapid removal of blood, in the presence and absence of the pericardium

Comparator

Baseline conditions and comparison between right and left ventricles

Outcome

Blood flow, myocardial O2 consumption (MVO2), and myocardial O2 extraction ratio (EO2)surrogate

The right ventricle demonstrates a greater reserve capacity for myocardial oxygen extraction compared to the left ventricle under conditions of volume loading and hypoperfusion in a canine model.

Cite This Study

Takeda et al. (1987) studied this question.

synapsesocial.com/papers/6a7b45fb756812e39589f13c https://doi.org/10.1253/jcj.51.563

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Myocardial oxygen metabolism of the right ventricle with volume loading and hypoperfusion.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Myocardial oxygen metabolism of the right ventricle with volume loading and hypoperfusion.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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