Why the study?
Does doubling cardiac inflow increase myocardial oxygen consumption in a canine right heart bypass preparation?
Does doubling cardiac inflow increase myocardial oxygen consumption in a canine right heart bypass preparation?
Doubling cardiac inflow increases myocardial oxygen consumption by approximately 10%, which is attributed to increased contractile element shortening and work.
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Informs experimental models of myocardial energetics; leaves open translation to human physiology.
Myocardial oxygen consumption (MVO2) was studied in a canine right heart bypass preparation. At constant heart rate and left ventricular peak developed tension (calculated from ventricular volume and pressure), doubling cardiac inflow increased MVO2 by 1·3 ml./100 g LV/min. This approximate 10% increase is attributed to increased contractile element shortening and work.
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Taylor et al. (1967) studied this question.
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