Myocardial oxygen consumption and the left ventricular pressure-volume area in normal and hypertrophic canine hearts.
Key result
Hypertrophic dog hearts show equivalent working efficiency to normal hearts based on similar MVO2-PVA relations.
- P NS
- n=16
Why the study?
The energy demands and mechanical efficiency of hypertrophic hearts compared to normal hearts were not well characterized.
Does myocardial energy demand differ between normal and hypertrophic canine hearts?
Population
Eight normal and eight hypertrophic dog hearts
Comparison
Hypertrophic hearts vs normal hearts
Design
Isolated, blood-perfused heart apparatus study
Authors
Discussion
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Implication
Hypertrophic canine hearts match normal myofibrillar efficiency and basal energy use; leaves open translation to human LVH energetics.
Structured PICO
Does myocardial energy demand differ between normal and hypertrophic canine hearts?
P
Population
16 isolated, blood-perfused dog hearts (8 normal and 8 hypertrophic) studied to assess energy demands.
E
Exposure
Assessment of myocardial oxygen consumption (MVO2) and left ventricular pressure-volume area (PVA) in an isolated, blood-perfused heart apparatus
C
Comparator
Normal dog hearts vs. hypertrophic dog hearts
O
Outcome
Relation between myocardial oxygen consumption (MVO2) and left ventricular pressure-volume area (PVA)surrogate
Main Result
Absolute Event Rate: 4.19% vs 3.89%
p-value: p=NS
Basal and nonworking energy demands and working efficiencies of hypertrophic canine hearts are equivalent to those of normal hearts.
Cite This Study
Izzi et al. (1991) studied Hypertrophy (n=16). Hypertrophy (aortic band model) vs. Normal hearts was evaluated on Slope of the MVO2-PVA relation (myofibrillar efficiency) (p=NS). The slope of the MVO2-PVA relation was similar in hypertrophic and normal dog hearts (4.19 vs 3.89 ml O2/mm Hg.ml.10(5), p = NS), indicating equivalent working efficiencies.