What question did this study set out to answer?

To evaluate if oxygen consumption rates are equal for isovolumic and ejecting contractions at the same systolic pressure-volume area in canine hearts.

November 1, 1981Circulation Research

Equal oxygen consumption rates of isovolumic and ejecting contractions with equal systolic pressure-volume areas in canine left ventricle.

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Why the study?

Does systolic pressure-volume area (PVA) reliably predict cardiac oxygen consumption (VO2) in canine left ventricles regardless of whether the contraction is isovolumic or ejecting?

Population

Canine left ventricles (n = 10 hearts, 32 pairs of contractions)

Comparison

Steady state entirely isovolumic contractions vs Variously ejecting contractions with equal…

Design

Preclinical

Authors

HSHiroyuki SugaShinshu University THTamaki HayashiNara Medical University SSS SuehiroChiba University

Discussion

Member takes

Implication

Supports PVA as contraction-mode-independent VO2 predictor in canine LV; leaves open human translation and clinical adoption.

Key Points

To evaluate if oxygen consumption rates are equal for isovolumic and ejecting contractions at the same systolic pressure-volume area in canine hearts.
Compared oxygen consumption rates for isovolumic and ejecting contractions in 10 canine hearts with equal pressure-volume areas.
Measured various hemodynamic parameters including stroke volume and end-diastolic volume during contractions.
Analyzed data from 32 paired contractions for statistical significance.
Oxygen consumption was similar for isovolumic (0.0375 +/- 0.0021 ml O2/beat) and ejecting contractions (0.0368 +/- 0.0021 ml O2/beat).
Measured pressure-volume areas were equal (1008 +/- 64 vs. 1022 +/- 62 mm Hg ml/beat).
Significant differences were noted in stroke volume, end-diastolic volume, and peak pressure between contraction types.

Structured PICO

Does systolic pressure-volume area (PVA) reliably predict cardiac oxygen consumption (VO2) in canine left ventricles regardless of whether the contraction is isovolumic or ejecting?

Population

Canine left ventricles (n = 10 hearts, 32 pairs of contractions)

Intervention

Steady state entirely isovolumic contractions

Comparator

Variously ejecting contractions with equal systolic pressure-volume areas (PVA)

Outcome

Cardiac oxygen consumption rate per beat (VO2)surrogate

Systolic pressure-volume area (PVA) is a reliable predictor of myocardial oxygen consumption in the canine left ventricle, independent of whether the contraction is isovolumic or ejecting.

Cite This Study

Suga et al. (1981) studied this question.

synapsesocial.com/papers/6a70abdefe4101aa97e0442d https://doi.org/10.1161/01.res.49.5.1082

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Equal oxygen consumption rates of isovolumic and ejecting contractions with equal systolic pressure-volume areas in canine left ventricle.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Equal oxygen consumption rates of isovolumic and ejecting contractions with equal systolic pressure-volume areas in canine left ventricle.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider