Key result
The integral of systolic force is the predominant factor regulating myocardial oxygen consumption, whereas the influence of fiber shortening is negligible.
Why the study?
Does the integral of systolic force or fiber shortening predominantly regulate myocardial oxygen consumption in isolated canine hearts?
Population
14 servo-regulated, paced, isolated canine hearts
Comparison
Assessment of the relative influence of load… vs Isovolumetrically beating versus ejecting…
Design
Preclinical
Authors
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Supports force integral as primary regulator in isolated canine hearts; leaves open translation to human physiology and practice.
Does the integral of systolic force or fiber shortening predominantly regulate myocardial oxygen consumption in isolated canine hearts?
In isolated canine hearts, myocardial oxygen consumption is predominantly determined by the integral of systolic force rather than fiber shortening.
Weber et al. (1977) studied this question. Wall force and shortening was evaluated on Myocardial O2 consumption (MVO2). The integral of systolic force is the predominant factor regulating myocardial oxygen consumption, whereas the influence of fiber shortening is negligible.
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