Effect of Alterations of Coronary Blood Flow on the Oxygen Consumption of the Nonworking Heart
Why the study?
Does varying coronary blood flow alter myocardial oxygen consumption in the nonworking dog heart?
Population
23 dog heart experiments with empty ventricles performing no external work
Comparison
Varying coronary blood flow and myocardial O2… vs Different levels of CBF
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
Should not inform clinical practice; leaves open whether coronary flow modulates MVO2 in working human hearts.
Structured PICO
Does varying coronary blood flow alter myocardial oxygen consumption in the nonworking dog heart?
P
Population
23 dog heart experiments (14 isolated perfused, 9 on cardiopulmonary bypass) with empty ventricles performing no external work
I
Intervention
Varying coronary blood flow (CBF) and myocardial O2 delivery
C
Comparator
Different levels of CBF (within-subject comparisons)
O
Outcome
Myocardial oxygen consumption (MVO2) calculated by the Fick principlesurrogate
In the nonworking dog heart, myocardial oxygen consumption is directly dependent on coronary blood flow, except when oxygen delivery greatly exceeds demand.
Cite This Study
Kahler et al. (1963) studied this question.