Key result
In isolated supported hearts, myocardial oxygen consumption did not vary with changes in coronary blood flow when heart activity was controlled, but varied directionally with ventricular tension.
Why the study?
Does changing coronary blood flow independently alter myocardial oxygen consumption in an isolated heart preparation?
Population
Isolated supported heart preparation
Comparison
Alteration of coronary blood flow or ventricular… vs Different levels of coronary blood flow or…
Design
Preclinical
Authors
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Highlights ventricular tension over coronary flow as primary driver of myocardial oxygen consumption; leaves open translation to intact human hearts.
Does changing coronary blood flow independently alter myocardial oxygen consumption in an isolated heart preparation?
Myocardial oxygen consumption is primarily determined by ventricular myocardial tension rather than coronary blood flow itself.
Sarnoff et al. (1963) studied this question. Varying coronary blood flow vs. Constant coronary blood flow was evaluated on Myocardial O2 consumption. In isolated supported hearts, myocardial oxygen consumption did not vary with changes in coronary blood flow when heart activity was controlled, but varied directionally with ventricular tension.
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