Hypoxia (10% and 5% oxygen) maintained total left ventricular oxygen consumption via increased coronary flow, while complete anoxia caused negative arteriovenous differences for lactate and pyruvate.
Normal intact dogs subjected to different degrees of hypoxia to study myocardial metabolism.
Hypoxia vs Baseline/normal oxygenation (10% oxygen, 5% oxygen, and complete anoxia)
Coronary blood flow and myocardial oxygen and carbohydrate metabolism
Coronary blood flow and myocardial oxygen and carbohydrate metabolism were studied in normal intact dogs subjected to different Degreess of hypoxia. Total left ventricular oxygen consumption was maintained during administration of 10 per cent and 5 per cent oxygen owing to increase in coronary flow and myocardial oxygen extraction. Ten per cent oxygen administration had little effect on carbohydrate uptake by the heart. Five per cent oxygen resulted in decreased coefficients of extraction for glucose, lactate and pyruvate, but total utilization was maintained. Complete anoxia resulted in negative arteriovenous differences for lactate and markedly decreased or negative values for pyruvate.
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Donald B. Hackel
University of Southern California
Walter T. Goodale
Illinois College
Jerome Kleinerman
Brigham and Women's Hospital
Circulation Research
Case Western Reserve University
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Hackel et al. (Mon,) conducted a other in Normal intact dogs. Hypoxia vs. Baseline/normal oxygenation was evaluated on Coronary blood flow and myocardial oxygen and carbohydrate metabolism. Hypoxia (10% and 5% oxygen) maintained total left ventricular oxygen consumption via increased coronary flow, while complete anoxia caused negative arteriovenous differences for lactate and pyruvate.
synapsesocial.com/papers/6a1f2bbee800cc4eef553d65 — DOI: https://doi.org/10.1161/01.res.2.2.169