Why the study?
Does adrenalectomy and thoracic sympathectomy alter coronary blood flow and myocardial metabolism during hypoxia in dogs?
Population
Dogs (two groups: intact animals and those subjected to adrenalectomy and thoracic sympathectomy)
Comparison
Adrenalectomy and thoracic sympathectomy prior… vs Intact animals exposed to hypoxia
Design
Preclinical
Authors
Loading...
Local metabolic factors predominate in hypoxic coronary vasodilation; leaves open translation to human physiology.
Does adrenalectomy and thoracic sympathectomy alter coronary blood flow and myocardial metabolism during hypoxia in dogs?
The increase in coronary blood flow during hypoxia is primarily driven by local metabolic factors rather than being necessarily mediated by cardiac sympathetic nerves or adrenal glands.
Hackel et al. (1956) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: