Why the study?
Does beta-adrenergic blockade or sympathectomy alter the cardiovascular response to acute severe hypoxia in anesthetized dogs?
Population
49 anesthetized dogs
Comparison
Beta-adrenergic blockade with pronethalol or… vs Sham-operated and intact untreated dogs during…
Design
Preclinical
Follow-up
15 minutes
Authors
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Beta-blockade may blunt hypoxic cardiac output rise in dogs; leaves open translation to conscious humans or clinical hypoxia.
Does beta-adrenergic blockade or sympathectomy alter the cardiovascular response to acute severe hypoxia in anesthetized dogs?
During acute hypoxia, stimulation of cardiac beta-adrenergic receptors by a humoral mechanism plays an important role in cardiovascular responses, while cardiac sympathetic nerves are not essential.
Chiong et al. (1972) studied this question.
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