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November 1, 1953Circulation ResearchOpen Access

Myocardial Carbohydrate Metabolism in Normal Dogs, with Effects of Hyperglycemia and Starvation

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Key result

Myocardial extraction of glucose, lactate, and pyruvate in normal dogs was directly related to arterial levels, with glucose as the main fuel at normal levels and fat during starvation.

Why the study?

How do hyperglycemia and starvation affect myocardial carbohydrate metabolism in normal dogs?

Population

Nembutalized normal intact dogs

Comparison

Hyperglycemia and starvation vs Normal resting state

Design

Preclinical

Authors

WGWalter T. GoodaleIllinois CollegeDHDonald B. HackelUniversity of Southern California

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Implication

Preclinical data from normal dogs should not guide human care; leaves open substrate metabolism in diseased myocardium.

Key Points

  • To analyze myocardial carbohydrate metabolism in normal dogs and assess the impacts of hyperglycemia and starvation.
  • Utilized coronary sinus catheterization technique in normal intact dogs.
  • Measured myocardial extraction of oxygen, glucose, lactate, and pyruvate.
  • Compared energy sources under different glucose conditions.
  • Glucose extraction was significant at arterial levels of 70 to 120 mg per cent, providing major fuel for energy.
  • In starvation, the heart relied on fat as an energy source, indicated by a respiratory quotient of near 0.70.
  • Pyruvate and lactate displayed high extraction rates but could not meet more than 50% of energy needs at low arterial levels.

Structured PICO

How do hyperglycemia and starvation affect myocardial carbohydrate metabolism in normal dogs?

P
Population
Nembutalized normal intact dogs evaluated for myocardial carbohydrate metabolism at rest, during hyperglycemia, and starvation.
E
Exposure
Hyperglycemia and starvation
C
Comparator
Normal resting state
O
Outcome
Myocardial extraction of oxygen, glucose, lactate, and pyruvatesurrogate

This preclinical study demonstrates that myocardial glucose extraction is dependent on arterial levels and that the heart shifts to fat metabolism during starvation.

Cite This Study

Goodale et al. (1953) studied Normal intact dogs. Hyperglycemia and starvation vs. Normal resting state was evaluated on Myocardial extraction of oxygen, glucose, lactate and pyruvate. Myocardial extraction of glucose, lactate, and pyruvate in normal dogs was directly related to arterial levels, with glucose as the main fuel at normal levels and fat during starvation.

synapsesocial.com/papers/6a1f2bbee800cc4eef553d66https://doi.org/10.1161/01.res.1.6.509
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Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1Measurement of Coronary Blood Flow in Dogs and Man from Rate of Myocardial Nitrous Oxide Desaturation1953 · 85 citations