Population
17 mongrel dogs of either sex, weighing 20-30 kg, subjected to acute regional low-flow myocardial ischemia…
Comparison
Infusion of [1-13C]glucose during a 3-4 hour… vs Nonischemic regions of the heart in the same dogs.
Design
Preclinical
Follow-up
3-4 hours
Authors
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Hypothesis-generating for substrate modulation in ischemia; requires human validation before any clinical consideration.
In a canine model of low-flow ischemia, ischemic myocardium upregulates cytosolic glucose utilization (glycolysis and glycogen synthesis) but continues to rely on fat as the major source of mitochondrial oxidative substrate.
McNulty et al. (1996) studied this question.
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