Population
Closed-chest chronically instrumented anesthetized dogs
Comparison
3 hours of intracoronary balloon occlusion of… vs Normal myocardium and baseline measurements
Design
Preclinical
Follow-up
1 month postreperfusion
Authors
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May confound FDG-PET viability assessment post-reperfusion; leaves open translation of remote metabolic shifts to humans.
In a canine model of ischemia-reperfusion, reversibly injured myocardium shows enhanced FDG uptake relative to normal myocardium at 24 hours postreperfusion due to a decrease in glucose metabolism in normal remote tissue.
Buxton et al. (1991) studied this question.
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