Why the study?
Does repetitive myocardial ischemia increase glucose uptake and glycogen levels in a swine model?
Population
13 swine instrumented with a hydraulic occluder on the circumflex (Cx) artery
Comparison
Repetitive myocardial ischemia vs Remote (non-ischemic) myocardial regions
Design
Preclinical
Follow-up
24 hours post-final ischemia
Authors
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Suggests metabolic shifts after repetitive ischemia in swine; hypothesis-generating and should not yet inform clinical practice.
Does repetitive myocardial ischemia increase glucose uptake and glycogen levels in a swine model?
Repetitive myocardial ischemia increases glucose uptake and glycogen levels in the postischemic region even after functional recovery, suggesting altered metabolic regulation.
McFalls et al. (2002) studied this question.