Key result
Myocardial stunning increases glucose uptake rate ~6-fold versus nonischemic control myocardium.
Why the study?
The study aimed to quantify myocardial glucose uptake and clarify the pathway of augmented glucose uptake in reperfused stunned myocardium after brief ischemia.
Does ischemia-reperfusion (stunning) increase glucose uptake via glucose transporters in rat myocardium?
Does ischemia-reperfusion (stunning) increase glucose uptake via glucose transporters in rat myocardium?
Absolute Event Rate: 1.03% vs 0.18%
p-value: p=<0.0001
Augmented glucose uptake in stunned myocardium is maintained by glucose transporters at a level comparable to maximal insulin stimulation.
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Findings in rat model should not alter clinical practice; extends metabolic insights in stunning but leaves open human translation.
Hashimoto et al. (1997) studied Stunned myocardium. Ischemia and reperfusion (stunned myocardium) vs. Nonischemic control myocardium was evaluated on Glucose uptake rate (d[SP]/dt) (p=<0.0001). Glucose uptake rate in stunned rat myocardium was significantly increased compared with nonischemic control myocardium (1.03 vs 0.18 micromol/g/min; P<0.0001), mediated by the glucose transporter.
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