April 1, 2000Journal of Biological ChemistryOpen Access

Preconditioning Enhanced Glucose Uptake Is Mediated by p38 MAP Kinase Not by Phosphatidylinositol 3-Kinase

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Why the study?

Does ischemic preconditioning enhance glucose uptake via p38 MAP kinase or PI3K in Langendorff-perfused rat hearts?

Structured PICO

Does ischemic preconditioning enhance glucose uptake via p38 MAP kinase or PI3K in Langendorff-perfused rat hearts?

Population

Langendorff-perfused rat hearts

Intervention

Ischemic preconditioning (4 cycles of 5 min ischemia and 5 min reperfusion) with or without inhibitors (wortmannin for PI3K, SB202190 for p38 MAP kinase)

Comparator

Control (nonpreconditioned) hearts with or without inhibitors

Outcome

Hexose transport measured from the rate of production of 2-deoxyglucose 6-phosphate (2DG6P) using (31)P nuclear magnetic resonancesurrogate

Ischemic preconditioning increases myocardial hexose transport through a p38 MAP kinase-dependent, PI3K-independent pathway.

Discussion

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Implication

p38-dependent glucose uptake in preconditioned rat hearts; leaves open translation to human cardioprotection.

Cite This Study

Tong et al. (2000) studied this question.

synapsesocial.com/papers/6a229a65cce2ba38c0cd4288 https://doi.org/10.1074/jbc.275.16.11981

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