Why the study?
Does ischemic preconditioning preserve mitochondrial function and glycolytic flux during reperfusion in perfused rat hearts?
Population
Perfused rat hearts
Comparison
Preconditioning before 40 min of sustained… vs Non-preconditioned group
Design
Preclinical
Follow-up
30 minutes of reperfusion
Authors
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Supports mitochondrial preservation in rat preconditioning; leaves open translation to human ischemia-reperfusion injury.
Does ischemic preconditioning preserve mitochondrial function and glycolytic flux during reperfusion in perfused rat hearts?
Ischemic preconditioning preserves mitochondrial function and facilitates glycolysis during reperfusion in rat hearts, which may play an important role in improving postischemic contractile function.
Yabe et al. (1997) studied this question.
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