Why the study?
Does ischemic preconditioning improve functional recovery and energy metabolism in rat isolated working hearts subjected to global ischemia?
Population
Rat isolated working hearts subjected to 20 min global ischaemia and reperfusion
Comparison
Preconditioning by three 5 min cycles or two 10… vs Langendorff perfusion prior to the ischaemic…
Design
Preclinical
Follow-up
20 min global ischaemia and 45 min reperfusion
Authors
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May aid recovery in rat ischemia models; hypothesis-generating and leaves open clinical translation.
Does ischemic preconditioning improve functional recovery and energy metabolism in rat isolated working hearts subjected to global ischemia?
Pre-ischaemic disturbances of energy metabolism, rather than activation of adenosine receptors or stunning, may contribute to the efficacy of multiple preconditioning in the rat isolated heart.
Писаренко et al. (1998) studied this question.
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