April 1, 1993Cardiovascular Research
Ischaemic and hypoxic preconditioning enhance postischaemic recovery of function in the rat heart
Why the study?
Does ischemic or hypoxic preconditioning improve postischemic recovery of function in isolated rat hearts?
Population
Isolated rat hearts
Comparison
Ischemic preconditioning or hypoxic… vs Control hearts (no preconditioning)
Design
Preclinical
Follow-up
30 min reperfusion
Authors
Discussion
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Member takes
Implication
Extends evidence for adenosine-independent cardioprotection in rodent models; leaves open translation to human ischemic heart disease.
Structured PICO
Does ischemic or hypoxic preconditioning improve postischemic recovery of function in isolated rat hearts?
P
Population
Isolated rat hearts
I
Intervention
Ischemic preconditioning (5 min ischemia) or hypoxic preconditioning (5 min hypoxia), with or without adenosine A1 antagonists (A1433U 10 microM or DPCPX 5 microM)
C
Comparator
Control hearts (no preconditioning)
O
Outcome
Recovery of left ventricular function assessed by percent recovery of preischemic rate-pressure product after 30 min ischemia and 30 min reperfusionsurrogate
Ischemic and hypoxic preconditioning enhance postischemic functional recovery in rat hearts through mechanisms not solely dependent on adenosine A1 receptors.
Cite This Study
Lasley et al. (1993) studied this question.